Article
Single B-cell deconvolution of peanut-specific antibody responses in allergic patients.
The Journal of allergy and clinical immunology - 1 Jan 2016
Hoh Ramona A, Joshi Shilpa A, Liu Yi, Wang Chen, Roskin Krishna M, Lee Ji-Yeun, Pham Tho, Looney Tim J, Jackson Katherine J L, Dixit Vaishali P, King Jasmine, Lyu Shu-Chen, Jenks Jennifer, Hamilton Robert G, Nadeau Kari C, Boyd Scott D
Abstract excerpt
BACKGROUND: The frequencies, cellular phenotypes, epitope specificity, and clonal diversity of allergen-specific B cells in patients with food allergy are not fully understood but are of major pathogenic and therapeutic significance. OBJECTIVE: We sought to characterize peanut allergen-specific B-cell populations and the sequences and binding activities of their antibodies before and during immunotherapy....
Topics
- 2S Albumins, Plant
- Adolescent
- Adult
- Allergens
- Antigens, Plant
- B-Lymphocytes
- Child
- Child, Preschool
- Desensitization, Immunologic
- Female