Article

Sequential Switching Through IgG1 is Redundant for Allergic Reactivity and Memory to Allergens

2023-05-28

Abstract excerpt

Allergic reactions to foods are driven by allergen-binding immunoglobulin (Ig)E antibodies. IgE- expressing cells can be generated through a sequential class switching pathway where activated B cells first switch to an intermediary isotype, most frequently IgG1, and then to IgE. It has been proposed that sequential class switch recombination is important in generating high affinity IgE, augmenting anaphylactic rea...

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Literature Corpus work: 49432b8a-6e13-5d7f-8c5c-78028e270dc2
DOI: 10.1101/2023.05.27.542563

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