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Article

Molecular Characterisation of the Haemagglutinin Glycan-Binding Specificity of Egg-Adapted Vaccine Strains of the Pandemic 2009 H1N1 Swine Influenza A Virus.

Molecules (Basel, Switzerland) - 5 Jun 2015

Carbone Vincenzo, Schneider Elena K, Rockman Steve, Baker Mark, Huang Johnny X, Ong Chi, Cooper Matthew A, Yuriev Elizabeth, Li Jian, Velkov Tony

Abstract excerpt

The haemagglutinin (HA) glycan binding selectivity of H1N1 influenza viruses is an important determinant for the host range of the virus and egg-adaption during vaccine production. This study integrates glycan binding data with structure-recognition models to examine the impact of the K123N, D225G and Q226R mutations (as seen in the HA of vaccine strains of the pandemic 2009 H1N1 swine influenza A virus). The...

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Identifiers

PMID: 26056814
DOI: 10.3390/molecules200610415
PMCID: PMC6272818

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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