Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential Antibody Recognition of H3N2 Vaccine and Seasonal Influenza Virus Strains Based on Age, Vaccine Status, and Sex in the 2017-2018 Season.

The Journal of infectious diseases - 14 Sept 2020

Ursin Rebecca L, Liu Hsuan, Powell Harrison R, Westerbeck Jason W, Shaw-Saliba Kathryn, Sylvia Kristyn E, Fenstermacher Katherine J, Mehoke Tom, Thielen Peter, Rothman Richard E, Pekosz Andrew, Klein Sabra L

Abstract excerpt

BACKGROUND: An antigenic mismatch between the vaccine and circulating H3N2 strains was hypothesized to contribute to the severity of the 2017-2018 season in North America. METHODS: Serum and nasal washes were collected from influenza positive and negative patients during the 2017-2018 season to determine neutralizing antibody (nAb) titers and for influenza virus sequencing, respectively. RESULTS: The circulating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibodies, Neutralizing
Share to Hemagglutinin Glycoproteins, Influenza Virus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Influenza A Virus, H3N2 Subtype

Share to Influenza, Human

Share to Influenza Vaccines

Share to Sex Factors

Share to United States

Share to Vaccination

Source

Open in PubMed Open full text

Identifiers

PMID: 32496543
DOI: 10.1093/infdis/jiaa289
PMCID: PMC7488199

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential Antibody Recognition of H3N2 Vaccine and Seasonal Influenza Virus Strains Based on Age, Vaccine Status, and Sex in the 2017-2018 Season.PMID 32496543Read ↗

In-depth phylogenetic analysis of the hemagglutinin gene of influenza A(H3N2) viruses circulating during the 2016-2017 season revealed egg-adaptive mutations of vaccine strains.Semantic proximity Read ↗

Poor Immunogenicity, Not Vaccine Strain Egg Adaptation, May Explain the Low H3N2 Influenza Vaccine Effectiveness in 2012-2013.Semantic proximity Read ↗

Identification of human vaccinees that possess antibodies targeting the egg-adapted hemagglutinin receptor binding site of an H1N1 influenza vaccine strainSemantic proximity Read ↗

Low 2012-13 influenza vaccine effectiveness associated with mutation in the egg-adapted H3N2 vaccine strain not antigenic drift in circulating viruses.Semantic proximity Read ↗

Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains.Semantic proximity Read ↗

Influenza Vaccine Effectiveness by A(H3N2) Phylogenetic Subcluster and Prior Vaccination History: 2016–2017 and 2017–2018 Epidemics in CanadaSemantic proximity Read ↗

Redirecting antibody responses from egg-adapted epitopes following repeat vaccination with recombinant or cell culture-based versus egg-based influenza vaccinesSemantic proximity Read ↗

A structural explanation for the low effectiveness of the seasonal influenza H3N2 vaccineSemantic proximity Read ↗

Influenza and Influenza Vaccine: A Review.Semantic proximity Read ↗

Egg-adaptive mutations in H3N2v vaccine virus enhance egg-based production without loss of antigenicity or immunogenicity.Semantic proximity Read ↗

Estimates of influenza vaccine effectiveness for 2007-2008 from Canada's sentinel surveillance system: cross-protection against major and minor variants.Semantic proximity Read ↗

Antigenic assessment of the H3N2 component of the 2019-2020 Northern Hemisphere influenza vaccineSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.