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Article

Contemporary H3N2 influenza viruses have a glycosylation site that alters binding of antibodies elicited by egg-adapted vaccine strains.

Proceedings of the National Academy of Sciences of the United States of America - 21 Nov 2017

Zost Seth J, Parkhouse Kaela, Gumina Megan E, Kim Kangchon, Diaz Perez Sebastian, Wilson Patrick C, Treanor John J, Sant Andrea J, Cobey Sarah, Hensley Scott E

Abstract excerpt

H3N2 viruses continuously acquire mutations in the hemagglutinin (HA) glycoprotein that abrogate binding of human antibodies. During the 2014-2015 influenza season, clade 3C.2a H3N2 viruses possessing a new predicted glycosylation site in antigenic site B of HA emerged, and these viruses remain prevalent today. The 2016-2017 seasonal influenza vaccine was updated to include a clade 3C.2a H3N2 strain; however, the...

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Identifiers

PMID: 29109276
DOI: 10.1073/pnas.1712377114
PMCID: PMC5703309

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