Article

Roscovitine exacerbates <i>Mycobacterium abscessus</i> infection by reducing NADPH oxidase-dependent neutrophil trafficking

2021-07-30

Abstract excerpt

Persistent neutrophilic inflammation associated with chronic pulmonary infection causes progressive lung injury and eventually death in individuals with cystic fibrosis (CF), a genetic disease caused by bi-allelic mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. We therefore examined whether Roscovitine, a cyclin-dependent kinase inhibitor that (in other conditions) reduces inflamm...

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Literature Corpus work: 3601cb6a-7a3b-5f7e-a6d9-ad0926f49838
DOI: 10.1101/2021.07.30.454490

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