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Reconstitution of the <i>S. aureus agr</i> quorum sensing pathway reveals a direct role for the integral membrane protease MroQ in pheromone biosynthesis

2021-12-30

Abstract excerpt

In Staphylococcus aureus , virulence is under the control of a quorum sensing (QS) circuit encoded in the accessory gene regulator ( agr ) genomic locus. Key to this pathogenic behavior is the production and signaling activity of a secreted pheromone, the autoinducing peptide (AIP), generated following the ribosomal synthesis and post-translational modification of a precursor polypeptide, AgrD, through two discr...

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Literature Corpus work
41627621-2b9d-5c4a-b3f0-a1063a5a7051
DOI
10.1101/2021.12.29.473670
Open publication

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Reconstitution of the <i>S. aureus agr</i> quorum sensing pathway reveals a direct role for the integral membrane protease MroQ in pheromone biosynthesisDOI 10.1101/2021.12.29.473670
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