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Increasing AIP Macrocycle Size Reveals Key Features of <i>agr</i> Activation in <i>Staphylococcus aureus</i>

20 Mar 2015

Abstract excerpt

The agr locus in the commensal human pathogen, Staphylococcus aureus, is a two-promoter regulon with allelic variability that produces a quorum-sensing circuit involved in regulating virulence within the bacterium. Secretion of unique autoinducing peptides (AIPs) and detection of their concentrations by AgrC, a transmembrane receptor histidine kinase, coordinates local bacterial population density with global...

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PMID: 25801678
DOI: 10.1002/cbic.201500006

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