Article
Structure, activity and evolution of the group I thiolactone peptide quorum-sensing system of Staphylococcus aureus.
Molecular microbiology - 1 Jul 2001
MDowell P, Affas Z, Reynolds C, Holden M T, Wood S J, Saint S, Cockayne A, Hill P J, Dodd C E, Bycroft B W, Chan W C, Williams P
Abstract excerpt
In Staphylococcus aureus, the agr locus is responsible for controlling virulence gene expression via quorum sensing. As the blockade of quorum sensing offers a novel strategy for attenuating infection, we sought to gain novel insights into the structure, activity and turnover of the secreted staphylococcal autoinducing peptide (AIP) signal molecules. A series of analogues (including the L-alanine and D-amino acid...
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