Article
Staphylococcus intermedius produces a functional agr autoinducing peptide containing a cyclic lactone.
Journal of bacteriology - 1 May 2005
Ji Guangyong, Pei Wuhong, Zhang Linsheng, Qiu Rongde, Lin Jianqun, Benito Yvonne, Lina Gerard, Novick Richard P
Abstract excerpt
The agr system is a global regulator of accessory functions in staphylococci, including genes encoding exoproteins involved in virulence. The agr locus contains a two-component signal transduction module that is activated by an autoinducing peptide (AIP) encoded within the agr locus and is conserved throughout the genus. The AIP has an unusual partially cyclic structure that is essential for function and that, in...
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