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An isogenic panel of single <i>App</i> knock-in mouse models of Alzheimer’s disease confers differential profiles of β-secretase inhibition and endosomal abnormalities

2021-08-24

Abstract excerpt

<h4>SUMMARY</h4> We previously developed single App knock-in mouse models of Alzheimer’s disease (AD) that harbor the Swedish and Beyreuther/Iberian mutations with or without the Arctic mutation ( App NL- G-F and App NL-F mice). These models showed the development of amyloid β peptide (Aβ) pathology, neuroinflammation and cognitive impairment with aging. We have now generated App knock-in mice devoid of the...

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Literature Corpus work
db0e0cb2-7454-5566-8297-49c1e308965c
DOI
10.1101/2021.08.22.457278
Open publication

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An isogenic panel of single <i>App</i> knock-in mouse models of Alzheimer’s disease confers differential profiles of β-secretase inhibition and endosomal abnormalitiesDOI 10.1101/2021.08.22.457278
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