Back to search

Article

α-Endosulfine regulates amyloid β 42 via the modulation of neprilysin activity

2020-10-08

Abstract excerpt

The neuropeptide somatostatin (SST) regulates amyloid β peptide (Aβ) catabolism by enhancing neprilysin (NEP)-catalyzed proteolytic degradation. However, the mechanism by which SST regulates NEP activity remains unclear. Here we report the identification by differential proteomics of α-endosulfine (ENSA), an endogenous ligand of the ATP-sensitive potassium (K ATP ) channel, as a negative regulator of NEP activity...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
fd7c5b31-c9dd-55f3-a2ac-468c9828e589
DOI
10.1101/2020.10.07.329318
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 10 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
α-Endosulfine regulates amyloid β 42 via the modulation of neprilysin activityDOI 10.1101/2020.10.07.329318
Neprilysin-sensitive amyloidogenic Aβ versus IDE-sensitive soluble Aβ: a probable mechanistic cause for sporadic Alzheimer’s diseaseSemantic proximity
Somatostatin receptor subtypes 1 and 4 redundantly regulate neprilysin, the major amyloid-beta degrading enzyme in brainSemantic proximity
Somatostatin slows Aβ plaque deposition in aged <i> APP <sup>NL-F/NL-F</sup> </i> mice by blocking Aβ aggregation in a neprilysin-independent mannerSemantic proximity
SORLA mediates endocytic uptake of proIAPP and protects against islet amyloid depositionSemantic proximity
Semagacestat Is a Pseudo-Inhibitor of γ-SecretaseSemantic proximity
Endo-lysosomal Aβ concentration and pH enable formation of Aβ oligomers that potently induce Tau missortingSemantic proximity
Biochemical Identification of the Neutral Endopeptidase Family Member Responsible for the Catabolism of Amyloid Peptide in the BrainSemantic proximity
Metalloprotease Meprin β Generates Nontoxic N-terminal Amyloid Precursor Protein Fragments in VivoSemantic proximity
Histidine 131 in presenilin 1 is the pH-sensitive residue that causes the increase in Aβ42 level in acidic pH.Semantic proximity
The carboxyl-terminus of BACE contains a sorting signal that regulates BACE trafficking but not the formation of total A(beta).Semantic proximity
Select a neighboring publication to make it the new centre.