Article

Down regulation of <i>Hmgcr</i> in response to Influenza A infection is independent of the IFN response in human cells

2019-06-03

Abstract excerpt

Previous studies have demonstrated that the product of the Interferon stimulated gene Ch25h , 25-Hydroxycholestrol, provides an immediate and rapid mechanism for down-regulating sterol biosynthesis, through the inhibition of Hmgcr gene expression and proteolytic degradation of HMGCR protein. Further studies provide evidence that inhibition of the sterol biosynthesis pathway by 25-HC has broad antiviral effects....

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Literature Corpus work: 41530f4e-0ec3-5d91-93f7-ae7c11f009e5
DOI: 10.1101/650465

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