Article

Ubiquitin E3 ligase mediated regulation of HMG-CoA Reductase

2018-01-01

Abstract excerpt

Loss-of-function genetic screens are a powerful approach to identify the genes involved in biological processes. For nearly a century, forward genetic screens in model organisms have provided enormous insight into many cellular processes. However, the difficulty in generating and recovering bi-allelic mutations in diploid cells severely hindered the performance of forward genetic screens in mammalian cells. The de...

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Literature Corpus work: 2cf9a568-7285-5afe-91f9-445a22f819da
DOI: 10.17863/cam.20825

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