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Cholesterol 25-hydroxylase is an interferon-inducible factor that protects against porcine reproductive and respiratory syndrome virus infection.

Veterinary microbiology - 1 Oct 2017

Song Zhongbao, Zhang Qiaoya, Liu Xuewei, Bai Juan, Zhao Yongxiang, Wang Xianwei, Jiang Ping

Abstract excerpt

Porcine reproductive and respiratory syndrome virus (PRRSV), a single-stranded, positive-sense RNA virus of the Arteriviridae family, has become a global health threat for swine. Cholesterol 25-hydroxylase (CH25H) is an enzyme that catalyzes oxidation of cholesterol to 25-hydroxycholesterol (25HC). The purpose of this study was to explore the antiviral activity of CH25H against PRRSV infection. We found that...

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Identifiers

PMID: 29103685
DOI: 10.1016/j.vetmic.2017.09.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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