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Article

Identification of Genes and Pathways Regulated by Lamin A in Heart.

Journal of the American Heart Association - 18 Aug 2020

Coste Pradas Jordi, Auguste Gaelle, Matkovich Scot J, Lombardi Raffaella, Chen Suet Nee, Garnett Tyrone, Chamberlain Kyle, Riyad Jalish Mahmud, Weber Thomas, Singh Sanjay K, Robertson Matthew J, Coarfa Cristian, Marian Ali J, Gurha Priyatansh

Abstract excerpt

Background Mutations in the LMNA gene, encoding LMNA (lamin A/C), causes distinct disorders, including dilated cardiomyopathies, collectively referred to as laminopathies. The genes (coding and noncoding) and regulatory pathways controlled by LMNA in the heart are not completely defined. Methods and Results We analyzed cardiac transcriptome from wild-type, loss-of-function (Lmna-/-), and gain-of-function (Lmna-/-...

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Topics

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Share to Epigenesis, Genetic
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lamin Type A

Share to Myocardium

Share to Regulatory Elements, Transcriptional

Share to RNA, Long Noncoding

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Source

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Identifiers

PMID: 32805188
DOI: 10.1161/JAHA.119.015690
PMCID: PMC7660829

Genes

LMNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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