Article

Indels allow antiviral proteins to evolve functional novelty inaccessible by missense mutations

2024-05-10

Abstract excerpt

Antiviral proteins often evolve rapidly at virus-binding interfaces to defend against new viruses. We investigated whether antiviral adaptation via missense mutations might face limits, which insertion or deletion mutations (indels) could overcome. We report one such case of a nearly insurmountable evolutionary challenge: the human anti-retroviral protein TRIM5α requires more than five missense mutations in its sp...

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Literature Corpus work: 413d60c2-f763-5549-a6b5-719c1a8f44dc
DOI: 10.1101/2024.05.07.592993

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