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Article

Viruses are a dominant driver of protein adaptation in mammals

17 May 2016

Abstract excerpt

Viruses interact with hundreds to thousands of proteins in mammals, yet adaptation against viruses has only been studied in a few proteins specialized in antiviral defense. Whether adaptation to viruses typically involves only specialized antiviral proteins or affects a broad array of virus-interacting proteins is unknown. Here, we analyze adaptation in ~1300 virus-interacting proteins manually curated from a set...

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PMID: 27187613
DOI: 10.7554/elife.12469

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