Article
Peripheral selection rather than thymic involution explains sudden contraction in naive CD4 T-cell diversity with age.
Proceedings of the National Academy of Sciences of the United States of America - 26 Dec 2012
Johnson Philip L F, Yates Andrew J, Goronzy Jörg J, Antia Rustom
Abstract excerpt
A diverse array of T cells is required for defense against pathogens. The naive CD4 T-cell repertoire reaches its peak diversity by early human adulthood and is maintained until older age. Surprisingly, around age 70, this diversity appears to plummet abruptly. A similar qualitative pattern holds for the CD4 T memory-cell population. We used mathematical models to explore different hypotheses for how such a loss...
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