Article

Early circulating strain of SARS-CoV-2 causes severe pneumonia distinct from that caused by variants of concern in mice transduced with an adenoviral vector expressing human ACE2

2022-05-06

Abstract excerpt

To analyze the molecular pathogenesis of SARS-CoV-2, a small animal model such as mice is needed: human ACE2, the receptor of SARS-CoV-2, needs to be expressed in the respiratory tract of mice. We conferred SARS-CoV-2 susceptibility in mice by using an adenoviral vector expressing hACE2 driven by an EF1α promoter with a leftward orientation. In this model, severe pneumonia like human COVID-19 was observed in SARS-...

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Literature Corpus work: 4128d170-4327-5e53-96b1-94de609f8be0
DOI: 10.21203/rs.3.rs-1267705/v2

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Early circulating strain of SARS-CoV-2 causes severe pneumonia distinct from that caused by variants of concern in mice transduced with an adenoviral vector expressing human ACE2DOI 10.21203/rs.3.rs-1267705/v2Read

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