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Article

Cosmc-dependent mucin-type O-linked glycosylation is essential for podocyte function.

American journal of physiology. Renal physiology - 1 Feb 2020

Stotter Brian R, Talbot Brianna E, Capen Diane E, Artelt Nadine, Zeng Junwei, Matsumoto Yasuyuki, Endlich Nicole, Cummings Richard D, Schlondorff Johannes S

Abstract excerpt

Mucin-type O-linked glycosylation, a posttranslational modification affecting the stability and biophysical characteristics of proteins, requires C1GalT1 (T synthase) and its obligate, X-linked chaperone Cosmc. Hypomorphic C1GalT1 mutations cause renal failure via not yet established mechanisms. We hypothesize that impaired Cosmc-dependent O-glycosylation in podocytes is sufficient to cause disease....

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Identifiers

PMID: 31904283
DOI: 10.1152/ajprenal.00399.2019
PMCID: PMC7052656

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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