Article

Variability in proteoglycan biosynthetic genes reveals new facets of heparan sulfates diversity. A systematic review and analysis

2022-04-18

Abstract excerpt

Proteoglycans are complex macromolecules formed of glycosaminoglycan chains covalently linked to core proteins through a linker tetrasaccharide common to heparan sulfate proteoglycans (HSPG) and chondroitin sulfate proteoglycans (CSPG). Biosynthesis of a single proteoglycan requires the expression of dozens of genes, which together create the large structural and functional diversity reflected by the numerous dise...

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Literature Corpus work: fa0a29b6-d91a-589c-a000-93acc75cc86c
DOI: 10.1101/2022.04.18.22273971

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