Article

Global view of domain-specific O-linked mannose glycosylation in glycoengineered cells

2024-01-16

Abstract excerpt

Protein O-linked mannose (O-Man) glycosylation is an evolutionary conserved post-translational modification (PTM) that fulfills important biological roles during embryonic development. Three non-redundant enzyme families, POMT1/POMT2, TMTC1-4 and TMEM260, selectively coordinate the initiation of protein O-Man glycosylation on distinct classes of transmembrane proteins, including α-dystroglycan, cadherins and plexi...

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Literature Corpus work: f22d2d9b-fee7-5999-bc7a-e6ad66479504
DOI: 10.1101/2024.01.15.575371

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