Article

Single-cell transcriptome analysis reveals CD34 as a novel marker of human sinoatrial node pacemaker cardiomyocytes

2024-09-07

Abstract excerpt

The sinoatrial node (SAN) regulates the heart rate throughout life. Failure of this primary pacemaker results in life-threatening, slow heart rhythm. Despite its important function, the cellular and molecular composition of the human SAN is not completely resolved. Particularly, no cell surface marker to identify and isolate SAN pacemaker cells has been reported to date. Here we used single-nuclei/cell RNA sequenc...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 411b080d-27aa-5341-aed1-1c621eb5093a
DOI: 10.1101/2024.09.06.611657

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell transcriptome analysis reveals CD34 as a novel marker of human sinoatrial node pacemaker cardiomyocytesDOI 10.1101/2024.09.06.611657Read

Single-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytesSemantic proximity Read

Subtype-specific differentiation of cardiac pacemaker cell clusters from human induced pluripotent stem cellsSemantic proximity Read

Engineering a pacemaker-driven human mini-heart guided by spatial and single cell multi-omics of sinoatrial node developmentSemantic proximity Read

Transcription factor ISL1 is essential for pacemaker development and functionSemantic proximity Read

Non-cardiomyocytes in the heart in embryo development, health, and disease, a single-cell perspectiveSemantic proximity Read

The single-cell atlas of the heart reveals an unexpected erythrocyte-like cardiomyocyteSemantic proximity Read

Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencingSemantic proximity Read

Integrated single-cell and spatial multiomic analysis reveals widespread reactivation of developmental programs in diseased human heartsSemantic proximity Read

Single‐Cell Atlas of Neonatal Mouse Hearts Reveals an Unexpected CardiomyocyteSemantic proximity Read

Transcriptome analysis of mouse and human sinoatrial node cells reveals a conserved genetic programSemantic proximity Read

Cells and gene expression programs in the adult human heartSemantic proximity Read

Same-Single-Cell Analysis of Pacemaker-Specific Markers in Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Subtypes Classified by ElectrophysiologySemantic proximity Read