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Cellular and molecular landscape of mammalian sinoatrial node revealed by single-cell RNA sequencing

12 Jan 2021

Abstract excerpt

Bioelectrical impulses intrinsically generated within the sinoatrial node (SAN) trigger the contraction of the heart in mammals. Though discovered over a century ago, the molecular and cellular features of the SAN that underpin its critical function in the heart are uncharted territory. Here, we identify four distinct transcriptional clusters by single-cell RNA sequencing in the mouse SAN. Functional analysis of...

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PMID: 33436583
DOI: 10.1038/s41467-020-20448-x

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