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Article

Transcription factor ISL1 is essential for pacemaker development and function

19 Jul 2015

Abstract excerpt

The sinoatrial node (SAN) maintains a rhythmic heartbeat; therefore, a better understanding of factors that drive SAN development and function is crucial to generation of potential therapies, such as biological pacemakers, for sinus arrhythmias. Here, we determined that the LIM homeodomain transcription factor ISL1 plays a key role in survival, proliferation, and function of pacemaker cells throughout...

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PMID: 26193633
DOI: 10.1172/jci68257

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