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Single-cell transcriptome analysis reveals CD34 as a marker of human sinoatrial node pacemaker cardiomyocytes

27 Nov 2024

Abstract excerpt

The sinoatrial node regulates the heart rate throughout life. Failure of this primary pacemaker results in life-threatening, slow heart rhythm. Despite its critical function, the cellular and molecular composition of the human sinoatrial node is not resolved. Particularly, no cell surface marker to identify and isolate sinoatrial node pacemaker cells has been reported. Here we use single-nuclei/cell RNA...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 39604360
DOI: 10.1038/s41467-024-54337-4

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