Article

Pharmacological profiling of a <i>Brugia malayi</i> muscarinic acetylcholine receptor as a putative antiparasitic target

2022-08-31

Abstract excerpt

The diversification of anthelmintic targets and mechanisms of action will help ensure the sustainable control of nematode infections in response to the growing threat of drug resistance. G protein-coupled receptors (GPCRs) are established drug targets in human medicine but remain unexploited as anthelmintic substrates despite their important roles in nematode neuromuscular and physiological processes. Bottlenecks...

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Literature Corpus work: 1a808e5a-adf7-53e7-8f1f-409c8336c45e
DOI: 10.1101/2022.08.31.506057

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