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Validation of a functional human AD model with four AD therapeutics utilizing patterned iPSC-derived cortical neurons integrated with microelectrode arrays

2024-05-20

Abstract excerpt

<title>Abstract</title> <p>Preclinical methods are needed for screening potential Alzheimer’s disease (AD) therapeutics that recapitulate phenotypes found in the Mild Cognitive Impairment (MCI) stage or even before this stage of the disease. This would require a phenotypic system that reproduces cognitive deficits without significant neuronal cell death to mimic the clinical manifestations of AD during these stag...

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Literature Corpus work
40c725b8-982e-5a36-8953-21ef23cf5ad6
DOI
10.21203/rs.3.rs-4313679/v1
Open publication

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Validation of a functional human AD model with four AD therapeutics utilizing patterned iPSC-derived cortical neurons integrated with microelectrode arraysDOI 10.21203/rs.3.rs-4313679/v1
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