Article

The Dystonia Gene THAP1 Controls DNA Double Strand Break Repair Choice

2020-07-19

Abstract excerpt

The Shieldin complex, consisting of SHLD1, SHLD2, SHLD3 and REV7, shields DNA double strand breaks (DSBs) from nucleolytic resection. The end-protecting activity of Shieldin promotes productive non-homologous end joining (NHEJ) in G1 but can threaten genome integrity during S-phase by blocking homologous recombination (HR). Curiously, the penultimate Shieldin component, SHLD1 is one of the least abundant mammalian...

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Literature Corpus work: 40c4a359-1b29-5d22-b7a1-fc843fb4c7f6
DOI: 10.1101/2020.07.19.210773

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