p31 comet promotes homologous recombination by inactivating REV7 through the TRIP13 ATPase

Abstract excerpt

Significance HORMA domain proteins play integral roles in several cellular processes such as mitosis, meiosis, and DNA repair. Intriguingly, despite their disparate cellular functions, the HORMA proteins MAD2, REV7, and HORMAD1/2 are controlled by a common regulatory circuit involving the ATPase TRIP13. Here, we extend this paradigm, showing that the adaptor protein p31 comet , known to mediate TRIP13 activity...

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