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Urinary Metabolomics Reveals Alterations of Aromatic Amino Acid Metabolism of Alzheimer's Disease in the Transgenic CRND8 Mice.

Current Alzheimer research - 1 Jan 2016

Tang Zhi, Liu Liangfeng, Li Yongle, Dong Jiyang, Li Min, Huang Jiandong, Lin Shuhai, Cai Zongwei

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative disorder, with amyloid plaques accumulation as the key feature involved in its pathology. To date, however, the biochemical changes in AD have not been clearly characterized. Here, we present that urinary metabolomics based on high resolution mass spectrometry was employed for delineation of metabolic alterations in transgenic CRND8 mice. In this...

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PMID: 26825095
DOI: 10.2174/1567205013666160129095340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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