Back to search

Article

Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in Osteoarthritis

2021-01-31

Abstract excerpt

Articular cartilage is a dense extracellular matrix-rich tissue that degrades following chronic mechanical stress, resulting in osteoarthritis (OA). The tissue has low intrinsic repair especially in aged and osteoarthritic joints. Here we describe three pro-regenerative factors; fibroblast growth factor 2 (FGF2), connective tissue growth factor, bound to transforming growth factor-beta (CTGF-TGFβ), and hepatoma-de...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
4081057c-8419-5d20-a4fa-87d0905b3c4c
DOI
10.1101/2021.01.31.428791
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Matrix-Bound Growth Factors are Released upon Cartilage Compression by an Aggrecan-Dependent Sodium Flux that is Lost in OsteoarthritisDOI 10.1101/2021.01.31.428791
Molecular and biophysical mechanisms regulating hypertrophic differentiation in chondrocytes and mesenchymal stem cellsSemantic proximity
The neuropeptide alpha calcitonin gene-related peptide impairs load-stimulated proteoglycan production of human chondrocytes via WNT activitySemantic proximity
Knee Joint Response to Mechanical Loading: Bounding Mechanotransduction with RehabilitationSemantic proximity
α2-Macroglobulin-Rich Serum As a Master Inhibitor of Inflammatory Factors Attenuates Cartilage Degeneration in a Mini Pig Model of Osteoarthritis Induced By “Idealized” Anterior Cruciate Ligament ReconstructionSemantic proximity
A Sustained-Release AMD3100-Hyaluronic Acid Complex Ameliorates Osteoarthritis by Promoting FHL1-Mediated Negative Feedback on SDF-1 SignalingSemantic proximity
The role of connective tissue growth factor (CTGF) in articular cartilageSemantic proximity
Assessment of glycosaminoglycan concentration <i>in vivo</i> by chemical exchange-dependent saturation transfer (gagCEST)Semantic proximity
The role of growth factor in the repair of articular cartilageSemantic proximity
Versican controlled by Lmx1b regulates hyaluronate density and hydration for semicircular canal morphogenesisSemantic proximity
Mechanical loading rescues mechanoresponsiveness in a human osteoarthritis explant model despite Wnt activationSemantic proximity
Integrins and stretch activated ion channels; putative components of functional cell surface mechanoreceptors in articular chondrocytes.Semantic proximity
Physiological tonicity improves human chondrogenic marker expression through nuclear factor of activated T-cells 5 in vitro.Semantic proximity
Select a neighboring publication to make it the new centre.