Article

Versican controlled by Lmx1b regulates hyaluronate density and hydration for semicircular canal morphogenesis

2024-05-08

Abstract excerpt

During inner ear semicircular canal morphogenesis in zebrafish, patterned canal-genesis zones express genes for extracellular matrix component synthesis. These include hyaluronan and the hyaluronan-binding chondroitin sulfate proteoglycan Versican, which are abundant in the matrices of many developing organs. Charged hyaluronate polymers play a key role in canal morphogenesis through osmotic swelling. However, the...

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Literature Corpus work: adf4a41a-a5a9-5497-9dff-e31d1c6b6c21
DOI: 10.1101/2024.05.07.592968

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