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A Sustained-Release AMD3100-Hyaluronic Acid Complex Ameliorates Osteoarthritis by Promoting FHL1-Mediated Negative Feedback on SDF-1 Signaling

2026-02-24

Abstract excerpt

<title>Abstract</title> <p>Background Osteoarthritis (OA) is a prevalent degenerative joint disease with limited therapeutic options. The Stromal Cell-Derived Factor-1 (SDF-1)/CXCR4 signaling pathway is a key driver of OA catabolism and inflammation. However, its downstream regulatory mechanisms are incompletely understood, and strategies for sustained intra-articular drug delivery are needed to effectively targ...

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Literature Corpus work
2de0c7f5-7cdf-553b-8d94-e03ac1a46ecd
DOI
10.21203/rs.3.rs-8832462/v1
Open publication

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A Sustained-Release AMD3100-Hyaluronic Acid Complex Ameliorates Osteoarthritis by Promoting FHL1-Mediated Negative Feedback on SDF-1 SignalingDOI 10.21203/rs.3.rs-8832462/v1
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