Article

The Genomic Loci of Specific Human tRNA Genes Exhibit Ageing-Related DNA Hypermethylation

2019-12-10

Abstract excerpt

The epigenome deteriorates with age, potentially impacting on ageing-related disease. Here, we interrogate the DNA methylation state of the genomic loci of human tRNA. Whilst arising from only ~46kb ( < 0.002% genome), this information transfer machinery is the second most abundant cellular transcript. tRNAs also control metabolic processes known to affect ageing, through core translational and additional regulat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0b6ce845-2ba4-5dd7-aaba-e4ebe9bbe092
DOI: 10.1101/870352

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The Genomic Loci of Specific Human tRNA Genes Exhibit Ageing-Related DNA HypermethylationDOI 10.1101/870352Read

Dysregulation of tRNA methylation in cancer: Mechanisms and targeting therapeutic strategiesSemantic proximity Read

Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAsSemantic proximity Read

tModBase: deciphering the landscape of tRNA modifications and their dynamic changes from epitranscriptome dataSemantic proximity Read

Human TRMT1 and TRMT1L paralogs ensure the proper modification state, stability, and function of tRNAsSemantic proximity Read

Characterization of Somatic Mutations in Human tRNA Genes Reveals Tumor-Specific Mutational Loads, and the Generation of tRNA Variants that Alter the Genetic CodeSemantic proximity Read

The expanding world of tRNA modifications and their disease relevanceSemantic proximity Read

Human TRMT2A methylates tRNA and contributes to translation fidelitySemantic proximity Read

Matching tRNA modifications in humans to their known and predicted enzymesSemantic proximity Read

TRMT2B is responsible for both tRNA and rRNA m <sup>5</sup> U-methylation in human mitochondriaSemantic proximity Read

Diversity of human tRNA genes from the 1000-genomes project.Semantic proximity Read

tRNA modifications: greasing the wheels of translation and beyondSemantic proximity Read

Mitochondrial tRNA methylation in Alzheimer’s disease and progressive supranuclear palsySemantic proximity Read