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Identification of pre-existing ubiquitous neoantigen-reactive tumor-infiltrating T-cells in a patient with metastatic pancreatic neuroendocrine tumor

2026-08-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Mutation-derived neoantigens, typically identified in primary tumors, are emerging therapeutic targets for personalized cancer vaccines and adoptive T-cell therapies. However, clinical efficacy of neoantigen-directed therapies in patients with metastatic disease remains limited, partly due to inter-site genetic heterogeneity. We investigated whether ubiquitous neoantigens–de...

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Literature Corpus work
76cf7a2c-8786-5326-aa1e-c28f87976db8
DOI
10.64898/2026.07.30.741721
Open publication

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Identification of pre-existing ubiquitous neoantigen-reactive tumor-infiltrating T-cells in a patient with metastatic pancreatic neuroendocrine tumorDOI 10.64898/2026.07.30.741721
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