Article

Effects of germline and somatic events in candidate BRCAness genes on breast-tumor signatures

2019-06-11

Abstract excerpt

<h4>Background</h4> Mutations in BRCA1 and BRCA2 cause deficiencies in homologous recombination repair (HR), resulting in repair of DNA double-strand breaks by the alternative non-homologous end-joining pathway, which is more error prone. HR deficiency of breast tumors is important because it is associated with better responses to platinum salt therapies and PARP inhibitors. Among other consequences of HR defic...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 40304702-056c-53c9-ae35-827fabeb1890
DOI: 10.1101/662874

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Effects of germline and somatic events in candidate BRCAness genes on breast-tumor signaturesDOI 10.1101/662874Read

Effects of germline and somatic events in candidate BRCA-like genes on breast-tumor signaturesSemantic proximity Read

HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures.Semantic proximity Read

Regulators of homologous recombination deficiency identified by machine learning using somatic multi-omics data.Semantic proximity Read

Tumor suppressor heterozygosity and homologous recombination deficiency mediate resistance to front-line therapy in breast cancerSemantic proximity Read

Comprehensive Genomic Characterization of Breast Tumors with BRCA1 and BRCA2 MutationsSemantic proximity Read

Development of a novel BRCAness score that predicts response to PARP inhibitorsSemantic proximity Read

Divergence of mutational signatures in association with breast cancer subtype.Semantic proximity Read

Non-BRCA1/BRCA2 high-risk familial breast cancers are not associated with a high prevalence of BRCAness.Semantic proximity Read

Validation of Genomic and Transcriptomic Models of Homologous Recombination Deficiency in a Real-World Pan-Cancer CohortSemantic proximity Read

Heterogeneity of genomic profile in patients with HER2-positive breast cancer.Semantic proximity Read

Pan-cancer association of DNA repair deficiencies with whole-genome mutational patterns.Semantic proximity Read

Integrating breast tumor homologous recombination deficiency status to aid germline<i>BRCA1</i>and<i>BRCA2</i>variant classificationSemantic proximity Read