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Heterogeneity of genomic profile in patients with HER2-positive breast cancer.

Endocrine-related cancer - 1 Mar 2020

Chen Bo, Zhang Guochun, Wei Guangnan, Wang Yulei, Guo Liping, Lin Jiali, Li Kai, Mok Hsiaopei, Cao Li, Ren Chongyang, Wen Lingzhu, Jia Minghan, Li Cheukfai, Hou Ting, Han-Zhang Han, Liu Jing, Balch Charles M, Liao Ning

Abstract excerpt

HER2-positive breast cancer is a biologically and clinically heterogeneous disease. Based on the expression of hormone receptors (HR), breast tumors can be further categorized into HR positive and HR negative. Here, we elucidated the comprehensive somatic mutation profile of HR+ and HR- HER2-positive breast tumors to understand their molecular heterogeneity. In this study, 64 HR+/HER2+ and 43 HR-/HER2+ stage...

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PMID: 31905165
DOI: 10.1530/ERC-19-0414

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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