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Article

Non-BRCA1/BRCA2 high-risk familial breast cancers are not associated with a high prevalence of BRCAness.

Breast cancer research : BCR - 14 Jun 2023

Andersen Lars V B, Larsen Martin J, Davies Helen, Degasperi Andrea, Nielsen Henriette Roed, Jensen Louise A, Kroeldrup Lone, Gerdes Anne-Marie, Lænkholm Anne-Vibeke, Kruse Torben A, Nik-Zainal Serena, Thomassen Mads

Abstract excerpt

BACKGROUND: Familial breast cancer is in most cases unexplained due to the lack of identifiable pathogenic variants in the BRCA1 and BRCA2 genes. The somatic mutational landscape and in particular the extent of BRCA-like tumour features (BRCAness) in these familial breast cancers where germline BRCA1 or BRCA2 mutations have not been identified is to a large extent unknown. METHODS: We performed whole-genome...

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Identifiers

PMID: 37316882
DOI: 10.1186/s13058-023-01655-y
PMCID: PMC10265777

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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