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Two distinct lipid transporters together regulate invasive filamentous growth in the human fungal pathogen <i>Candida albicans</i>

2022-08-31

Abstract excerpt

Flippases transport lipids across the membrane bilayer to generate and maintain asymmetry. The human fungal pathogen Candida albicans has 5 flippases, including Drs2, which is critical for filamentous growth and phosphatidylserine (PS) distribution. Furthermore, a drs2 deletion mutant is hypersensitive to the antifungal drug fluconazole and copper ions. We show here that such a flippase mutant also has an altere...

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Identifiers and source

Literature Corpus work
40101750-6ea6-552c-9cc2-f1af0ac2ebca
DOI
10.1101/2022.08.30.505893
Open publication

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