Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6.

Oncoimmunology - 1 Jan 2020

Czerwinska Patrycja, Rucinski Marcin, Wlodarczyk Nikola, Jaworska Anna, Grzadzielewska Iga, Gryska Katarzyna, Galus Lukasz, Mackiewicz Jacek, Mackiewicz Andrzej

Abstract excerpt

We developed a therapeutic, gene-modified, allogeneic melanoma vaccine (AGI-101H), which, upon genetic modification, acquired melanoma stem cell-like phenotype. Since its initial clinical trial in 1997, the vaccine has resulted in the long-term survival of a substantial fraction of immunized patients (up to 20 years). Here, we investigated the potential molecular mechanisms underlying the long-lasting effect of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Vaccines
Share to Melanoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neoplastic Stem Cells

Share to Phenotype

Share to Proto-Oncogene Proteins c-bcl-6

Share to T-Lymphocytes

Source

Open in PubMed Open full text

Identifiers

PMID: 32002306
DOI: 10.1080/2162402X.2019.1710063
PMCID: PMC6959432

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Therapeutic melanoma vaccine with cancer stem cell phenotype represses exhaustion and maintains antigen-specific T cell stemness by up-regulating BCL6.PMID 32002306Read ↗

BCL11B targeting in tumor CD8 <sup>+</sup> T cells amplifies anti-tumor response by blocking exhaustion while promoting stemness and cytotoxicitySemantic proximity Read ↗

Cancer vaccination drives Nanog-dependent evolution of tumor cells toward an immune-resistant and stem-like phenotype.Semantic proximity Read ↗

Evolution and modulation of antigen-specific T cell responses in melanoma patientsSemantic proximity Read ↗

BET inhibitor in combination with BCG vaccine enhances antitumor efficacy and orchestrates T cell reprogramming for melanomaSemantic proximity Read ↗

Inflammatory regulation of stem-like cells in melanoma.Semantic proximity Read ↗

Spatiotemporal dynamics of adoptively transferred stem-like CD8 <sup>+</sup> T cells in the tumor microenvironment following vaccinationSemantic proximity Read ↗

IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapySemantic proximity Read ↗

Vaccination rescues dysfunctional T cell therapy by amplifying rare stem-like antitumor CD8⁺ T cellsSemantic proximity Read ↗

Changes in the TCRβ Repertoire and Tumor Immune Signature From a Cutaneous Melanoma Patient Immunized With the CSF-470 Vaccine: A Case Report.Semantic proximity Read ↗

Modulating the differentiation status of ex vivo-cultured anti-tumor T cells using cytokine cocktails.Semantic proximity Read ↗

Genome editing iPSC to purposing enhancement of induce CD8 killer T cell function for regenerative immunotherapySemantic proximity Read ↗

Melanoma stem cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.