Type I interferon dysregulation drives distinct pathogenic pathways in early- and late-onset lupus nephritis

Abstract excerpt

OBJECTIVES: Lupus nephritis (LN) is a leading cause of morbidity and mortality in systemic lupus erythematosus (SLE), affecting nearly half of the patients with SLE. Type I interferon (IFN) plays a central role in SLE and LN pathogenesis. This study explored the differential expression of type I IFN gene signatures (IFNGS) in renal tissues from early- and late-onset LN patients to uncover pathways linked to...

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