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Article

A novel mechanism of synaptic and cognitive impairments mediated via microRNA-30b in Alzheimer's disease

3 Dec 2018

Abstract excerpt

BACKGROUND: It is widely accepted that cognitive and memory deficits in Alzheimer's disease (AD) primarily result from synaptic failure. However, the mechanisms that underlie synaptic and cognitive dysfunction remain unclear. METHODS: We utilized molecular biology techniques, electrophysiological recordings, fluorescence in situ hybridization (FISH), immuno- and Golgi-staining, chromatin immunoprecipitation...

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PMID: 30522932
DOI: 10.1016/j.ebiom.2018.11.059

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