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Article

Single-Cell Transcriptomic Analysis Identifies a Unique Pulmonary Lymphangioleiomyomatosis Cell

30 Jun 2020

Abstract excerpt

Abstract Rationale Lymphangioleiomyomatosis (LAM) is a metastatic neoplasm of reproductive-age women associated with mutations in tuberous sclerosis complex genes. LAM causes cystic remodeling of the lung and progressive respiratory failure. The sources and cellular characteristics of LAM cells underlying disease pathogenesis remain elusive. Objectives Identification and characterization of LAM cells in human...

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PMID: 32603599
DOI: 10.1164/rccm.201912-2445oc

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