Article

Connectivity analysis of single cell RNA-sequencing derived transcriptional signature of lymphangioleiomyomatosis

2020-10-06

Abstract excerpt

<h4>ABSTRACT</h4> Lymphangioleiomyomatosis (LAM) is a rare pulmonary disease affecting women of childbearing age that is characterized by the aberrant proliferation of smooth-muscle (SM)-like cells and emphysema-like lung remodeling. In LAM, mutations in TSC1 or TSC2 genes results in the activation of the mechanistic target of rapamycin complex 1 (mTORC1) and thus sirolimus, an mTORC1 inhibitor, has been approved...

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Literature Corpus work: dd6aa784-6345-536b-bbdb-a361badf04c7
DOI: 10.1101/2020.09.30.320473

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