Article

Pooled genetic screens identify breast cancer risk genes involved in evasion from T cell-mediated killing

2024-05-13

Abstract excerpt

Genome-wide association studies have identified more than 220 loci associated with breast cancer susceptibility. A major challenge is now to identify the effector genes with plausible functions in the context of breast cancer risk. We have previously performed pooled CRISPR screens to identify target genes at risk loci that drive cancer hallmarks including proliferation or modulating DNA damage response. We now ex...

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Literature Corpus work: 3fc620eb-8698-5f83-b4b8-9d44b30b30f8
DOI: 10.1101/2024.05.10.593465

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