Article

Double knockout CRISPR screen in cancer resistance to T cell cytotoxicity

2022-03-02

Abstract excerpt

Immunotherapy has transformed cancer treatments; however, a large fraction of patients encounter resistance. Such resistance is mediated by complex factors, often involving interactions between multiple genes. Thus, it is crucially important to identify genetic interactions between genes that are significantly mutated in cancer patients and those involved in immune responses, ideally the ones that currently have c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 60bfb3db-53e4-5675-bd16-fba3b7399f3b
DOI: 10.1101/2022.03.01.482556

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Double knockout CRISPR screen in cancer resistance to T cell cytotoxicityDOI 10.1101/2022.03.01.482556Read

Genome-Wide CRISPR Screening Identifies JAK1 Deficiency as a Mechanism of T-Cell ResistanceSemantic proximity Read

CRISPR Double Knockout Library Reveals Synthetic Lethal Gene Pairs in Triple-Negative Breast CancerSemantic proximity Read

Identifying chemogenetic interactions from CRISPR knockout screens with drugZSemantic proximity Read

CRISPR activation screen identifies BCL-2 proteins and B3GNT2 as drivers of cancer resistance to T cell-mediated cytotoxicitySemantic proximity Read

TCPGdb: A comprehensive T cell perturbation genomics database for identification of critical T cell regulatorsSemantic proximity Read

Multi-modal pooled Perturb-CITE-Seq screens in patient models define novel mechanisms of cancer immune evasionSemantic proximity Read

Applying CRISPR-based genetic screens to identify drivers of tumor-cell sensitivity towards NK-cell attackSemantic proximity Read

Novel CRISPR-Associated Gene-Editing Systems Discovered in Metagenomic Samples Enable Efficient and Specific Genome EngineeringSemantic proximity Read

CRISPR-GEMM Pooled Mutagenic Screening Identifies KMT2D as a Major Modulator of Immune Checkpoint Blockade.Semantic proximity Read

An Isogenic Cell Line Panel for Sequence-based Screening of Targeted Anti-cancer DrugsSemantic proximity Read

Dual genome-wide CRISPR knockout and CRISPR activation screens identify common mechanisms that regulate the resistance to multiple ATR inhibitorsSemantic proximity Read

Dual genome-wide CRISPR knockout and CRISPR activation screens identify mechanisms that regulate the resistance to multiple ATR inhibitorsSemantic proximity Read