Article

Intercellular CRISPR Screens Enhance the Discovery of Cancer Immunotherapy Targets

2022-03-04

Abstract excerpt

Cancer immunotherapy works through the interplay between immune and cancer cells. Particularly, interactions between cytotoxic T lymphocytes (CTLs) and cancer cells, such as PDCD1 (PD-1) and CD274 (PD-L1), are crucial for removing cancer cells. However, immune checkpoint inhibitors targeting these interactions are effective only to a subset of patients, requiring the development of novel immunotherapy drugs with...

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Literature Corpus work: 702348c4-841d-533d-b265-4c18a11b3e92
DOI: 10.1101/2022.03.03.482805

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