Article
CRISPR-Cas13d screens identify KILR, a breast cancer risk-associated lncRNA that regulates DNA replication and repair.
Molecular cancer - 15 May 2024
Wang Lu, Bitar Mainá, Lu Xue, Jacquelin Sebastien, Nair Sneha, Sivakumaran Haran, Hillman Kristine M, Kaufmann Susanne, Ziegman Rebekah, Casciello Francesco, Gowda Harsha, Rosenbluh Joseph, Edwards Stacey L, French Juliet D
Abstract excerpt
BACKGROUND: Long noncoding RNAs (lncRNAs) have surpassed the number of protein-coding genes, yet the majority have no known function. We previously discovered 844 lncRNAs that were genetically linked to breast cancer through genome-wide association studies (GWAS). Here, we show that a subset of these lncRNAs alter breast cancer risk by modulating cell proliferation, and provide evidence that a reduced expression...
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